Confirmation of Organized Modularity in the Yeast Interactome

June 2007 | Volume 5 | Issue 6 | e153 Confi rmation of Organized Modularity in the Yeast Interactome Nicolas Bertin, Nicolas Simonis, Denis Dupuy, Michael E. Cusick, Jing-Dong J. Han, Hunter B. Fraser, Frederick P. Roth, Marc Vidal A recent PLoS Biology article [1] rejected the conclusions of two previous publications [2,3] that two categories of highly connected “hub” proteins—“date” and “party” hubs—have distinct properties in the Saccharomyces cerevisiae interactome network. Currently available protein–protein interaction datasets are vastly incomplete, even for yeast [4]. Therefore, it is reasonable to rigorously re-scrutinize global properties of interactome networks as new datasets become available. Here we show that distinctions between date and party hubs [2], previously shown in a high-quality fi ltered yeast interactome (FYI) dataset [2,3], are in fact confi rmed in an updated literature-curated yeast interactome network.